Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus replication through in silico screening

  • 03/06/2022
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Aryamav Pattnaik, Nicholas Palermo, Bikash R Sahoo, Zhe Yuan, Duoyi Hu, Arun S Annamalai, Hiep L X Vu, Ignacio Correas, Pavan Kumar Prathipati, Christopher J Destache, Qingsheng Li, Fernando A Osorio, Asit K Pattnaik, Shi-Hua Xiang Zika virus (ZIKV), an emerging arbovirus, has become a major human health concern globally due to its association with congenital abnormalities and neurological diseases. Licensed vaccines or antivirals against ZIKV are currently […]

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Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated and Defective in Neuroinvasion

  • 03/06/2022
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Arun S. Annamalai, Aryamav Pattnaik, Bikash R. Sahoo, Ezhumalai Muthukrishnan, Sathish Kumar Natarajan, David Steffen, Hiep L. X. Vu, Gustavo Delhon, Fernando A. Osorio, Thomas M. Petro, Shi-Hua Xiang, Asit K. Pattnaik Zika virus (ZIKV), a mosquito-transmitted flavivirus responsible for sporadic outbreaks of mild and febrile illness in Africa and Asia, reemerged in the last decade causing serious human diseases, including microcephaly, congenital malformations, and Guillain-Barré syndrome. Although genomic and phylogenetic analyses suggest that genetic evolution may have […]

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